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This metabolic shift promotes lactylation of certain nuclear genes related to cell adhesion and migration, such as SOX10, thereby enhancing the migratory capacity of NCCs [178]

Recent studies have reported the various strategies used to inhibit glutamine metabolism have discrete effects on CD8 + T cells, emphasizing that targeting the same pathway with different modes may result in conflicting metabolic and functional consequences, further highlighting the importance of understanding how glutamine precisely affects the metabolic pathways and functional dynamics of different immune cell subpopulations in TME [224]

Symptom prevalence (number of scores 2) and moderate symptom prevalence (4) for total, upper, and lower GI GSRS clusters were analyzed using contingency tables

doi: 10.1007/s43188-020-00056-z

Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: A systematic analysis for the Global Burden of Disease Study 2021